A Drug for IDH1 Glioma Seemed to Help Some Tumors More Than Others
Original title: Ivosidenib in predominantly recurrent IDH1-mutant glioma: A single-institution experience.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This looked back at people who already took the drug, but it was not a trial.
The short version
A look back at people with glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary that came back found that the drug ivosidenib seemed to work best for certain tumors.
What was studied. Doctors at one hospital looked back at the records of adults with IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary who took a drug called ivosidenib. Most had a tumor that came back after other treatment. The group had 61 people with astrocytoma and 31 with oligodendroglioma.
What they found. The drug seemed to hold off tumor growth longest in lower-grade tumors. For grade 2 astrocytoma, the typical time before the tumor grew again was 15.2 months. For grade 4, it was 2.1 months. Tumors with fewer gene changes, and people with less past treatment, also did better.
What this means, and what it doesn't
What it could mean: If you have an IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary that came back, this drug may be worth asking your doctor about. It may help most when the tumor is lower grade and has had less treatment before.
What it doesn't mean: This study only looked back at past records from one hospital. It did not compare the drug to other care, so it cannot prove the drug caused these results. It does not show the drug helps every glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary. It is not a cure.
Source: PubMed, April 27, 2026 · Read the original
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